Designed as a thesis study in the early 1950s by student Oscar Fernandez, Autódromo Hermanos Rodríguez has hosted many of the world's most iconic racing series over its storied history. From what is now known as the Mexico City Grand Prix to the NASCAR Cup Series' first-ever event outside of the United States in 2025, the track has evolved numerous times over the years to accommodate different vehicles and advances in driver safety.

Most of Autódromo Hermanos Rodríguez's layouts, including the current 2.67-mile Grand Prix layout, feature a lengthy front straightaway into a right-angle, right-handed first corner. Top-tier open-wheel cars can reach a top speed exceeding 220 miles per hour before this initial braking zone. Also unique to the venue is the Foro Sol section, which sends drivers through baseball stadium seating; this same area of the track has also been used for the 2019 Race of Champions. The Autódromo also boasts a flat, one-mile oval that can both host stock car races and serve as the basis for shorter road racing layouts.