After half a century's worth of events on public roads were brought to an abrupt halt in 1970, Autodromo Internazionale del Mugello was constructed in 1973 and opened a year later to bring premier racing events back to the area. It quickly became host to major sports car events, lower-level open-wheel series, and grand prix motorcycle racing, for which it has hosted the Italian motorcycle Grand Prix for the past 30 years. In the COVID-19 impacted 2020 World Driver's Championship, it hosted the series for the first time with the Tuscan Grand Prix.

Mugello features two layouts: its 3.259-mile, 15-turn Grand Prix layout, and a 1.4-mile Short configuration. Both start with its lengthy front straightaway and go into the 180-degree San Donato right-hander before heading into Luco and Poggio Secco. The track has been owned by Scuderia Ferrari since 1988, which uses it for both testing and the Ferrari Challenge Finali Mondiali; the Tuscan Grand Prix in 2020 marked its 1000th Grand Prix event.